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Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic.

著者 Cheng F , Yuan G , He J , Shao Y , Zhang J , Guo X
Diagn Pathol.2020 Feb 24 ; 15(1):18.
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Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to be a target gene of microRNA-214 (miR-214) in our study. This study sought to assess the expression and clinical value of miR-214 in obese patients with IR, and investigate its therapeutic potential in obese rats and adipocytes with IR.
PMID: 32093712 [PubMed - in process]
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