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新型肺炎 中国国内の死者82人 北京で50歳の男性死亡

中国で感染が拡大している新型のコロナウイルスについて、北京市の保健当局は27日、新たに50歳の男性が死亡したと発表しました。北京市で死者が確認されたのは初めてで...

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Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma.

著者 Wang JY , Yang Y , Ma Y , Wang F , Xue A , Zhu J , Yang H , Chen Q , Chen M , Ye L , Wu H , Zhang Q
Biomed Pharmacother.2020 Jan ; 121():109627.
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Osteosarcoma (OS) is one of the most common malignant bone tumors in childhood and adolescence. Although great efforts have been made in therapeutic methods for OS, the prognosis is not yet satisfactory and the underlying molecular mechanisms of OS pathogenesis have not been fully explored. Meanwhile, non-coding RNAs, especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have long been investigated due to their roles as key players in regulating various biological and pathological processes, such as proliferation, apoptosis, cell-cycle, migration, invasion, metastasis, EMT and drug resistance, through targeting their mRNAs transcriptionally or posttranscriptionally. Although, numerous studies have confirmed a complex cross-regulation among lncRNAs, miRNAs and mRNAs, the underlying molecular mechanism has not been elucidated. In this review, we comprehensively summarized the latest research progress of the regulatory relationship among lncRNAs, miRNAs and mRNAs, and highlighted the role of lncRNA-miRNA-mRNA axis in the development of OS to provide novel approaches for cancer diagnosis and treatment.
PMID: 31810120 [PubMed - in process]
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