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新型ウイルス肺炎 北朝鮮国営航空 外国人観光客は乗せない対応

中国で新型のコロナウイルスによるものとみられる肺炎への感染が広がっている問題を受けた北朝鮮の動きです。北朝鮮国営のコリョ(高麗)航空はNHKの取材に対し、北京か...

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Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2 mutated extramammary Paget's disease.

著者 Nordmann TM , Messerli-Odermatt O , Meier L , Micaletto S , Coppetti T , Nägeli M , Kamarachev J , Kudura K , Freiberger SN , Rordorf T , Mangana J , Braun R , Dummer R
Oncotarget.2019 Nov 19 ; 10(62):6647-6650.
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Metastatic extramammary Paget's disease is a rare adenocarcinoma with poor prognosis. Several reports of human epidermal growth factor receptor 2 alterations point to its pathogenic role in the disease. However, the occurrence of treatment resistance to anti-HER2 therapy demand the need for further knowledge. We report of a patient with metastatic penoscrotal extramammary Paget's disease, with an mutation, in which near complete response was achieved upon treatment with trastuzumab and carboplatin. However, after 10 cycles of trastuzumab and carboplatin, widespread metastasis re-occurred. Analysis of a newly developing metastasis revealed additional genomic alterations including ERBB3 and point mutations as well as and amplification, providing a potential mechanism of acquired treatment resistance. Therefore, family inhibitor afatinib was initiated. Unfortunately, the patient succumbed to disease-related complications shortly after treatment initiation. This is the first report of mutated, metastatic extramammary Paget's disease with secondary resistance to trastuzumab / carboplatin, potentially due to additional acquired genomic alterations. This case contributes to the growing evidence of HER2 in the pathogenesis of metastatic extramammary Paget's disease and emphasizes the importance of repetitive, genomic analysis in rare diseases.
PMID: 31803359 [PubMed]
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