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Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet.

著者 Wallenius V , Elias E , Elebring E , Haisma B , Casselbrant A , Larraufie P , Spak E , Reimann F , le Roux CW , Docherty NG , Gribble FM , Fändriks L
Gut.2019 Nov 21 ; ():.
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Food intake normally stimulates release of satiety and insulin-stimulating intestinal hormones, such as glucagon-like peptide (GLP)-1. This response is blunted in obese insulin resistant subjects, but is rapidly restored following Roux-en-Y gastric bypass (RYGB) surgery. We hypothesised this to be a result of the metabolic changes taking place in the small intestinal mucosa following the anatomical rearrangement after RYGB surgery, and aimed at identifying such mechanisms.
PMID: 31753852 [PubMed - as supplied by publisher]
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