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Antibodies against nephronectin ameliorate anti-type II collagen-induced arthritis in mice.

著者 Kon S , Honda M , Ishikawa K , Maeda M , Segawa T
FEBS Open Bio.2019 Nov 09 ; ():.
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The extracellular matrix protein Nephronectin (Npnt) is known to be critical for kidney development, but its function in inflammatory diseases is unknown. Here, we developed a new ELISA system to detect Npnt in various autoimmune diseases, which revealed that plasma Npnt levels are increased in various mouse autoimmune models. We also report that antibodies against the α8β1 integrin-binding region of Npnt protect mice from anti-type II collagen-induced arthritis, suggesting that Npnt may be a potential therapeutic target molecule for the prevention of autoimmune arthritis.
PMID: 31705832 [PubMed - as supplied by publisher]
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