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新型肺炎 中国国内の死者82人 北京で50歳の男性死亡

中国で感染が拡大している新型のコロナウイルスについて、北京市の保健当局は27日、新たに50歳の男性が死亡したと発表しました。北京市で死者が確認されたのは初めてで...

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Generalized Verrucosis Revealing a Life-Threatening and Unlabeled T-Cell Lymphopenia Associated With Autoimmune Hemolytic Anemia: A Case Report and Review of Literature.

著者 Marxgut M , Adjaoud D , Aladjidi N , Armari C , Marxgut L , Rubio A
J Pediatr Hematol Oncol.2019 Sep 19 ; ():.
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Primary immunodeficiencies are inherited disorders, which may be revealed in the context of autoimmune hemolytic anemia (AIHA). We report the case of a girl presenting with an enterovirus-related AIHA. Despite being in complete remission for her anemia after treatment, the initial CD4/CD8 lymphopenia dramatically worsened with time. Its sole clinical presentation was generalized verrucosis. Cellular quantitative and functional immunodeficiency was evidenced but no known molecular defect was identified despite extensive workup. This unlabeled profound naive T-lymphopenia was cured by bone marrow transplantation. No similar case was ever described in the scientific literature. Patients with AIHA and/or generalized verrucosis should be screened for primary immunodeficiency, before initiating any immunomodulatory treatment.
PMID: 31568177 [PubMed - as supplied by publisher]
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