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Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction-Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial.

著者 Kwong RY , Heydari B , Ge Y , Abdullah S , Fujikura K , Kaneko K , Harris WS , Jerosch-Herold M , Antman EM , Seidman JG , Pfeffer MA
PLoS One.2019 ; 14(9):e0222061.
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The double-blind OMEGA-REMODEL placebo-controlled randomized trial of high-dose omega-3 fatty acids (O-3FA) post-acute myocardial infarction (AMI) reported improved cardiac remodeling and attenuation of non-infarct myocardial fibrosis. Fatty acid desaturase 2 (FADS2) gene cluster encodes key enzymes in the conversion of essential omega-3 and omega-6 fatty acids into active arachidonic (ArA) and eicosapentaenoic acids (EPA), which influence cardiovascular outcomes.
PMID: 31532795 [PubMed - in process]
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