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Vaccine approaches for the 'therapeutic management' of subspecies infection in domestic livestock.

著者 Gupta S , Singh SV , Singh M , Chaubey KK , Karthik K , Bhatia AK , Kumar N , Dhama K
Vet Q.2019 Sep 16 ; ():1-18.
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High endemicity of Johne's disease (JD) in herds adversely affects heavy milk yielding breeds by reducing the per animal productivity and 'productive life-span'.This review evaluates different vaccines used for its control and summarizes the benefits of 'global vaccine' in the four major domestic livestock species, namely goat, sheep, buffalo and cattle. Vaccines developed by using 'native strains' revealed both 'therapeutic' and preventive effects in domestic livestock. The 'therapeutic' role of vaccine in animals suffering from clinical JD turned out to be valuable in some cases by reversing the disease process and animals returning back to health and production. Good herd management, improved hygiene, 'test and cull' methodology, disposal of animal excreta and monitoring of MAP bio-load were also regarded as crucial in the 'therapeutic' management of JD. Vaccine approaches have been widely adopted in JD control programs and may be considered as a valuable adjunct in order to utilize huge populations of otherwise un-productive livestock. It has been shown that vaccination was the preeminent strategy to control JD, because it yielded approximately 3-4 times better benefit-to-cost ratios than other strategies. Internationally, 146 vaccine trials/studies have been conducted in different countries for the control of JD and have shown remarkable reduction in its national prevalence. It is concluded that for Johne's disease, there cannot be global vaccines or diagnostic kits as solutions have to come from locally prevalent strains of MAP. Despite some limitations, vaccines might still be an effective strategy to reduce or eradicate JD.
PMID: 31524561 [PubMed - as supplied by publisher]
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