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ノーベル化学賞の吉野さん 理事長務める大阪の研究施設に出勤

ノーベル化学賞に選ばれた吉野彰さんが、受賞決定後初めて、自身が理事長を務める大阪府内のリチウムイオン電池の研究施設に出勤し、研究への変わらぬ意欲を示しました。

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Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.

著者 Clement RL , Daccache J , Mohammed MT , Diallo A , Blazar BR , Kuchroo VK , Lovitch SB , Sharpe AH , Sage PT
Nat Immunol.2019 Sep 02 ; ():.
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Follicular regulatory T (T) cells have specialized roles in modulating follicular helper T (T) cell activation of B cells. However, the precise role of T cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still unclear due to a lack of specific tools. A T cell-deleter mouse was developed that selectively deletes T cells, facilitating temporal studies. T cells were found to regulate early, but not late, germinal center (GC) responses to control antigen-specific antibody and B cell memory. Deletion of T cells also resulted in increased self-reactive immunoglobulin (Ig) G and IgE. The increased IgE levels led us to interrogate the role of T cells in house dust mite models. T cells were found to control T13 cell-induced IgE. In vivo, loss of T cells increased house-dust-mite-specific IgE and lung inflammation. Thus, T cells control IgG and IgE responses to vaccines, allergens and autoantigens, and exert critical immunoregulatory functions before GC formation.
PMID: 31477921 [PubMed - as supplied by publisher]
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