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子どもを早産 親どうしがアプリを使い交流 悩みなど相談 (NHK)

早産などで産まれた赤ちゃんの親どうしが、自宅にいながら交流できる機会をつくろうと、当事者たちがスマートフォンなどのアプリを使った対面式の交流会に取り組んでいます...

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The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens.

著者 Hao X , Wang X , Hu J , Gu M , Wang J , Deng Y , Jiang D , He D , Xu H , Yang Y , Hu Z , Chen S , Hu S , Liu X , Shang S , Peng D , Jiao X , Liu X
Virology.2019 Jul 08 ; 535():218-226.
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Genotype S H9N2 viruses frequently donate their internal genes to facilitate the generation of novel influenza viruses, e.g., H5N6, H7N9, and H10N8, which have caused human infection. Genotype S was originated from the replacement of F/98-like M and PB2 genes of the genotype H with those from G1-like lineage. However, whether this gene substitution will influence the viral fitness of emerging influenza viruses remains unclear. We found that H5Nx and H7N9 viruses with G1-like PB2 or M gene exhibited higher virulence and replication than those with F/98-like PB2 or M in chickens. We also determined the functional significance of G1-like PB2 in conferring increased polymerase activity and improved nucleus transportation efficiency, and facilitated RNP nuclear export by G1-like M. Our results suggest that G1-like PB2 and M genes optimize viral fitness, and thus play a crucial role in the genesis of emerging influenza viruses that cause rising prevalence in chickens.
PMID: 31325836 [PubMed - as supplied by publisher]
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