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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

著者 Wong JYY , Zhang H , Hsiung CA , Shiraishi K , Yu K , Matsuo K , Wong MP , Hong YC , Wang J , Seow WJ , Wang Z , Song M , Kim HN , Chang IS , Chatterjee N , Hu W , Wu C , Mitsudomi T , Zheng W , Kim JH , Seow A , Caporaso NE , Shin MH , Chung LP , An SJ ,
Genomics.2019 Jul 12 ; ():.
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We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
PMID: 31306748 [PubMed - as supplied by publisher]
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