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Integrative analysis identifies genetic variant modulating MICA expression and altering susceptibility to persistent HBV infection.

著者 Gong Y , Cheng X , Tian J , Li J , Zhu Y , Yang Y , Zou D , Peng X , Luo J , Zhao L , Mei S , Wang X , Yang N , Ke J , Gong J , Chang J , Wang Y , Zhong R
Liver Int.2019 Apr 29 ; ():.
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Genome-wide association studies (GWASs) have identified multiple genetic signals associated with the risk of persistent hepatitis B virus (HBV) infection and HBV-related hepatocellular carcinoma. However, the majority of the associated variants may only be markers of functional variants and the underlying biological mechanisms remain elusive. We hypothesized that the functional variants with modulating transcription factor (TF) binding affinity in GWAS-identified loci may influence the risk of persistent HBV infection in Chinese people.
PMID: 31033131 [PubMed - as supplied by publisher]
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