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CD8 T cell exhaustion.

著者 Kurachi M
Semin Immunopathol.2019 Apr 15 ; ():.
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CD8 T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8 T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8 T cells to gradual deterioration of T cell function, a state called "exhaustion." Exhausted T cells are characterized by progressive loss of effector functions (cytokine production and killing function), expression of multiple inhibitory receptors (such as PD-1 and LAG3), dysregulated metabolism, poor memory recall response, and homeostatic proliferation. These altered functions are closely related with altered transcriptional program and epigenetic landscape that clearly distinguish exhausted T cells from normal effector and memory T cells. T cell exhaustion is often associated with inefficient control of persisting infections and cancers, but re-invigoration of exhausted T cells with inhibitory receptor blockade can promote improved immunity and disease outcome. Accumulating evidences support the therapeutic potential of targeting exhausted T cells. However, exhausted T cells comprise heterogenous cell population with distinct responsiveness to intervention. Understanding molecular mechanism of T cell exhaustion is essential to establish rational immunotherapeutic interventions.
PMID: 30989321 [PubMed - as supplied by publisher]
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