絞り込み

16598

広告

どうするどうなる介護医療院 (日経BP)

2018年度介護保険制度改正で創設された「介護医療院」について、日本慢性期医療協会会長の武久洋三氏が解説した書籍。介護医療院は、長期療養と生活施設の両機能を兼ね...

  1. 5年ぶり改訂、高血圧治療ガイドラインが発...
  2. 海賊版「アクセス警告方式」にも異論噴出 ...
  3. 血圧目標、臨床データは米政府系機関「尊重...
  4. バンクシー作品に似た“ネズミ” 都庁に展...

ニュース一覧

Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug resistant bacteria.

著者 Wu C , Shang Z , Lemetre C , Ternei MA , Brady SF
J Am Chem Soc.2019 Feb 08 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)

Full Text Sources

The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are active against resistant pathogens. Calcium-dependent antibiotics are a small family of structurally diverse acidic lipopeptides assembled by non-ribosomal peptide synthetases (NRPSs) that are known to display various modes of action against antibiotic-resistant pathogens. Here we use NRPS adenylation (AD) domain sequencing to guide the identification, recovery and cloning of the cde biosynthetic gene cluster from a soil metagenome. Heterologous expression of the cde biosynthetic gene cluster led to the production of cadasides A (1) and B (2), a sub-family of acidic lipopeptides that is distinct from previously characterized calcium-dependent antibiotics in terms of both overall structure and acidic residue rich peptide core. The cadasides inhibit the growth of multidrug-resistant Gram-positive pathogens by disrupting cell wall biosynthesis in the presence of high concentrations of calcium. Interestingly, sequencing of AD domains from diverse soils found that sequences predicted to arise from cadaside-like gene clusters are predominantly found in soils containing high levels of calcium carbonate.
PMID: 30735616 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード