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microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints.

著者 Nakamura A , Rampersaud YR , Nakamura S , Sharma A , Zeng F , Rossomacha E , Ali SA , Krawetz R , Haroon N , Perruccio AV , Mahomed NN , Gandhi R , Rockel JS , Kapoor M
Ann Rheum Dis.2018 Oct 04 ; ():.
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We recently identified microRNA-181a-5p (miR-181a-5p) as a critical mediator involved in the destruction of lumbar facet joint (FJ) cartilage. In this study, we tested if locked nucleic acid (LNA) miR-181a-5p antisense oligonucleotides (ASO) could be used as a therapeutic to limit articular cartilage degeneration.
PMID: 30287418 [PubMed - as supplied by publisher]
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