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キンギョの「設計図」解読 (デイリースポーツ)

キンギョのゲノム(全遺伝情報)解読に初めて成功したと、大阪大などのチームが26日付の米科学誌電子版に発表した。ゲノムは生物の設計図ともいわれ、さまざまな形態を持...

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Cardiac Management of the Patient With Duchenne Muscular Dystrophy.

著者 Buddhe S , Cripe L , Friedland-Little J , Kertesz N , Eghtesady P , Finder J , Hor K , Judge DP , Kinnett K , McNally EM , Raman S , Thompson WR , Wagner KR , Olson AK
Pediatrics.2018 Oct ; 142(Suppl 2):S72-S81.
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Duchenne muscular dystrophy (DMD) results in a progressive cardiomyopathy that produces significant morbidity and mortality. To improve the quality of life in patients with DMD, cardiac care is focused on surveillance and management, with the goal of slowing the onset and progression of heart failure complications. The current article is intended to be an expanded review on the cardiac management data used to inform the 2018 DMD Care Considerations recommendations as well as be a discussion on clinical controversies and future management directions. The new cardiac guidance includes changes regarding noninvasive imaging surveillance of cardiac function and pharmacologic therapy. Many emerging therapies lack sufficient evidence-based data to be recommended in the 2018 DMD Care Considerations. These are discussed in the present article as clinical controversies and future directions. Important emerging therapies include new heart failure medications, mechanical circulatory support with ventricular assist devices, heart transplantation, and internal cardiac defibrillators. Future research studies should be focused on the risks and benefits of these advanced therapies in patients with DMD. We conclude this review with a brief discussion on the relationship between the heart and the recently developed medications that are used to directly target the absence of dystrophin in DMD.
PMID: 30275251 [PubMed - in process]
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