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ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.

著者 Wang W , Friedland SC , Guo B , O'Dell MR , Alexander WB , Whitney-Miller CL , Agostini-Vulaj D , Huber AR , Myers JR , Ashton JM , Dunne RF , Steiner LA , Hezel AF
Gut.2018 Sep 18 ; ():.
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Here, we evaluate the contribution of AT-rich interaction domain-containing protein 1A (), the most frequently mutated member of the SWItch/sucrose non-fermentable (SWI/SNF) complex, in pancreatic homeostasis and pancreatic ductal adenocarcinoma (PDAC) pathogenesis using mouse models.
PMID: 30228219 [PubMed - as supplied by publisher]
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