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Prevalence and predictors of liver fibrosis evaluated by vibration controlled transient elastography in type 1 Gaucher disease.

著者 Nascimbeni F , Cassinerio E , Dalla Salda A , Motta I , Bursi S , Donatiello S , Spina V , Cappellini MD , Carubbi F
Mol Genet Metab.2018 Aug 11 ; ():.
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Long-term liver-related complications of Gaucher disease (GD) include cirrhosis, portal hypertension and hepatocellular carcinoma. Although liver fibrosis is the main determinant of adverse liver-related clinical outcomes, it has rarely been evaluated in previously published cohorts of GD patients. We aimed at: assessing the prevalence of significant liver fibrosis in a cohort of patients with type 1 GD; identifying its predictors among GD-related variables, enzyme replacement therapy (ERT) and metabolic features.
PMID: 30115580 [PubMed - as supplied by publisher]
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