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D-lactic Acidosis: Successful Suppression of D-lactate-Producing by Probiotics.

著者 Yilmaz B , Schibli S , Macpherson AJ , Sokollik C
Pediatrics.2018 Aug 08 ; ():.
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Intestinal microbiota composition in children with short bowel syndrome (SBS) is an important factor influencing the clinical outcome. An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment. Antibiotic treatments for D-lactic acidosis in children with SBS offer often only short-term relief. Here, we present the case of a boy with SBS who developed recurrent episodes of D-lactic acidosis even under continuous cycling antibiotic treatment. Microbiological analyses were used to detect the presence of D-lactate-producing species in the stool samples. A probiotic cocktail was introduced to alter the intestinal microbiota. During follow-up under treatment with probiotics, the patient remained stable, and there was no additional need for antibiotic therapy for more than a year. Stool composition of the patient was sequenced regularly over that period. His microbiota profile changed completely in species richness, and a clustering of species according to probiotic usage was seen. Importantly, D-lactate-producing strains disappeared within a few weeks after probiotic introduction and were no longer detected in the subsequent follow-up specimens.
PMID: 30089656 [PubMed - as supplied by publisher]
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