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Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.

著者 Schafer PH , Ye Y , Wu L , Kosek J , Ringheim G , Yang Z , Liu L , Thomas M , Palmisano M , Chopra R
Ann Rheum Dis.2018 Jun 26 ; ():.
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and encoding transcription factors Ikaros and Aiolos) are susceptibility loci for systemic lupus erythematosus (SLE). The pharmacology of iberdomide (CC-220), a cereblon () modulator targeting Ikaros and Aiolos, was studied in SLE patient cells and in a phase 1 healthy volunteer study.
PMID: 29945920 [PubMed - as supplied by publisher]
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