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Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease.

著者 Schmitt H , Billmeier U , Dieterich W , Rath T , Sonnewald S , Reid S , Hirschmann S , Hildner K , Waldner MJ , Mudter J , Hartmann A , Grützmann R , Neufert C , Münster T , Neurath MF , Atreya R
Gut.2018 May 30 ; ():.
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Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn's disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF therapy.
PMID: 29848778 [PubMed - as supplied by publisher]
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