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Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.

著者 Ikuta K , Fukuda A , Ogawa S , Masuo K , Goto N , Hiramatsu Y , Tsuda M , Kimura Y , Matsumoto Y , Kimura Y , Maruno T , Kanda K , Nishi K , Takaori K , Uemoto S , Takaishi S , Chiba T , Nishi E , Seno H
Gut.2018 May 24 ; ():.
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Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic development, homeostasis and the formation of pancreatic ductal adenocarcinoma (PDA).
PMID: 29798841 [PubMed - as supplied by publisher]
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