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Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats.

著者 Laadraoui J , Bezza K , El Gabbas Z , Marhoume F , Wakrim EM , Ferehan H , Aboufatima R , Sokar Z , Kissani N , Chait A
Epilepsy Behav.2017 Dec 28 ; 79():154-161.
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Tobacco smoking is considered the greatest risk factor for early death caused by noncommunicable diseases. Currently, there are more than one billion tobacco smokers in the world predisposed to many diseases including heart attack, stroke, cancer, and premature birth or birth defects related to the consumption of cigarettes. However, studies on the association between tobacco smoking and seizures or epilepsy are insufficient and not well documented. In the present study, the authors examined the convulsive effects of the intracerebroventricular administration of cigarette smoke condensate (CSC, 2μl/Rat) in rats and compared it with the intensity of seizures in the kainic acid (KA)-induced seizure model of epilepsy. The role of the cholinergic system was also investigated by testing the effect of the muscarinic acetylcholine receptors (mAChRs) antagonist atropine (2ml/kg) on CSC-induced seizures. The results indicate that a central injection of CSC produces an epileptic behavior similar to that induced by KA, the similarities include the following parameters: time latency of seizures, latency and duration of tonic-clonic seizures, duration of seizures, survival, and tonic-clonic rate. However, a pretreatment with atropine reduced seizures and all their parameters.
PMID: 29289903 [PubMed - as supplied by publisher]
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