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羽織はかま本庶さん、現地「日本の伝統的正装」 (読売新聞)

晩さん会で歓談する本庶佑・京都大特別教授(左端)と妻・滋子さん(右端)ら(10日午後、ストックホルムで)=代表撮影 【ストックホルム=諏訪智史、山本美菜子】「科...

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Drug nanocrystals (NCs) with fascinating physicochemical properties have attracted great attention in drug delivery. High drug-loading efficiency, great structural stability, steady dissolution, and long circulation time are a few examples of these properties, which makes drug NCs an excellent formulation for efficient cancer therapy. In the last two decades, there are a lot of hydrophobic or lipophilic drugs, such as paclitaxel (PTX), camptothecin (CPT), thymectacin, busulfan, cyclosporin A, 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH), and so on, which have been formulated into drug NCs for cancer therapy. In this review, we summarized the recent advances in drug NCs-based cancer treatment. So far, there are main three methods to synthesize drug NCs, including top-down, bottom-up, and combination methods. The characterization methods of drug NCs were also elaborated. Furthermore, the applications and mechanisms of drug NCs were introduced by their administration routes. At the end, we gave a brief conclusion and discussed the future perspectives of drug NCs in cancer therapy. For further resources related to this article, please visit the WIREs website.
PMID: 29044971 [PubMed - as supplied by publisher]
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