絞り込み

16530

広告

大飯原発訴訟 住民側が上告断念 敗訴確定へ

福井県にある大飯原子力発電所3号機と4号機について、住民らが関西電力に運転しないよう求めた裁判で、住民側は、17日、最高裁判所に上告しない方針を明らかにしました...

  1. 西日本豪雨の災害ごみ、中川環境相「広域処...
  2. ジェームズ・ウェッブ宇宙望遠鏡、今年2度...
  3. 版画・彫刻家の浜田知明さん死去 戦争テー...
  4. 俳優の生田悦子さん死去 (NHK)

ニュース一覧

Emerging combination therapies for the management of multiple myeloma: the role of elotuzumab.

著者 Chen WC , Kanate AS , Craig M , Petros WP , Hazlehurst LA
Cancer Manag Res.2017 ; 9():307-314.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (170view , 0users)

Full Text Sources

Miscellaneous

Treatment options for patients with multiple myeloma (MM) have increased during the past decade. Despite the significant advances, challenges remain on which combination strategies will provide the optimal response for any given patient. Defining optimal combination strategies and corresponding companion diagnostics, that will guide clinical decisions are required to target relapsed or refractory multiple myeloma (RRMM) in order to improve disease progression, survival and quality of life for patients with MM. Elotuzumab is a humanized monoclonal antibody that targets signaling lymphocytic activation molecule F7 (SLAMF7), approved by the US Food and Drug Administration (FDA) in 2015 and the European Medicines Agency in 2016 for the treatment of MM. SLAMF7 is expressed in normal and malignant plasma cells and has lower expression on natural killer (NK) cells. Experimental evidence indicates that elotuzumab exhibits anti-myeloma activity through 1) antibody-dependent cell-mediated cytotoxicity, 2) enhancing NK cells cytotoxicity and 3) interfering with adhesion of MM cells to bone marrow stem cells (BMSCs). Although elotuzumab has no single agent activity in patients with RRMM who have received one to three prior therapies, the combination of elotuzumab with anti-myeloma agents, such as immunomodulatory drugs-lenalidomide, or proteasome inhibitors (PIs)-bortezomib, remarkably improved the overall response rates and progression-free survival in MM patients with only minimal incremental toxicity. In brief, the clinical data for elotuzumab indicate that targeting SLAMF7 in combination with the use of conventional therapies is feasible and effective with a tolerable safety profile for the treatment of RRMM.
PMID: 28744161 [PubMed]
印刷用ページを開く Endnote用テキストダウンロード