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Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products.

著者 van der Velden NS , Kälin N , Helf MJ , Piel J , Freeman MF , Künzler M
Nat Chem Biol.2017 Jun 05 ; ():.
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Peptide backbone N-methylation, as seen in cyclosporin A, has been considered to be exclusive to nonribosomal peptides. We have identified the first post-translationally modified peptide or protein harboring internal α-N-methylations through discovery of the genetic locus for the omphalotins, cyclic N-methylated peptides produced by the fungus Omphalotus olearius. We show that iterative autocatalytic activity of an N-methyltransferase fused to its peptide substrate is the signature of a new family of ribosomally encoded metabolites.
PMID: 28581484 [PubMed - as supplied by publisher]
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