絞り込み

16241

広告

NHK全国短歌大会開かれる (NHK)

全国の愛好家から寄せられた、優れた短歌を紹介する「NHK全国短歌大会」が東京・渋谷のNHKホールで開かれました。 NHKとNHK学園が毎年開いている大会には、一...

  1. 高浜2号機の工事、一部作業中断 (デイリ...
  2. 高浜2号機の工事、一部作業中断 クレーン...
  3. 【2017年2月19日(日)開催】社会起...
  4. 「知能は遺伝する」を行動遺伝学が究明~あ...

ニュース一覧

Rapid analysis of drug dissolution by paper spray ionization mass spectrometry.

著者 Liu Y , Liu N , Zhou YN , Lin L , He L
J Pharm Biomed Anal.2016 Dec 23 ; 136():106-110.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)
  • このエントリーをはてなブックマークに追加

Full Text Sources

With a great quantity of solid dosage tested by dissolution technology, developing a rapid and sensitive method to access the content of drug within dissolution media is highly desired by analysts and scientists. Traditionally, dissolution media is not compatible with mass spectrometry since the inorganic salts in the media might damage the mass spectrometer. Here, paper spray ionization mass spectrometry (PSI-MS), one of the ambient mass spectrometry technologies, is developed to characterize the content of drugs in dissolution media. The porous structure of paper can effectively retain salts from entering mass spectrometer. This makes the measurement of drug content within dissolution media by mass spectrometer possible. After the experimental parameters were optimized, calibration curves of model drugs - enalapril, quinapril and benazepril were established by using corresponding deuterated internal standards. PSI-MS was then deployed to characterize the content of enalapril from the dissolution testing of enalapril tablets. The results from PSI-MS are comparable to those from HPLC characterization. More importantly, the analysis time of 6 samples is shortened from 90min to 6min. Detection limit of enalapril maleate tablets by PSI-MS is 1/300 of LC. PSI-MS is rapid, sensitive and accurate in analyzing drug content from dissolution tests.
PMID: 28068517 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード