Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.

Paulzen M , Haen E , Gründer G , Lammertz SE , Stegmann B , Schruers KR , Walther S , Schoretsanitis G
Journal of psychopharmacology (Oxford, England)
Treatment of arterial hypertension in patients with severe mental illnesses often results in polypharmacy, potentially leading to drug-drug interactions. The objective of the study was to analyse the in vivo inhibitory potential of two antihypertensive drugs, amlodipine and metoprolol on CYP2D6 catalysed 9-hydroxylation of risperidone (RIS).

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