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Adult-onset Still's disease (AOSD) is a rare systemic inflammatorydisorder of unknown etiology. The mainstaysof treatment are glucocorticoids (GCs) and non-steroidalanti-inflammatory drugs, although most cases are refractoryto these conventional therapies. Immunosuppressants,such as methotrexate (MTX), cyclosporine A, tumor necrosisfactor-α blockers, an interleukin (IL)-1 blocker, and an IL-6,receptor blocker, have been suggested in previous reports forthe treatment of steroid-resistant AOSD. We report hereinthe case of an AOSD patient who was successfully treatedwith tacrolimus, another immunosuppressant, in combinationwith GC and MTX. Blood concentrations of tacrolimuswere monitored because of the narrow therapeutic window.
PMID: 26535602 [PubMed - as supplied by publisher]