絞り込み

16645

広告

新型ウイルス対応医師ら職場で“バイ菌”扱い 学会が抗議声明

新型コロナウイルスの集団感染が起きたクルーズ船などで、対応を行った医師や看護師らが職場などで不当な扱いを受けているとして、災害対応を行う医療関係者でつくる学会が...

  1. 新型肺炎 インフルエンザ治療薬など使用 ...
  2. 新型肺炎 クルーズ下船後に陽性 栃木の6...
  3. 【動画】「dry cough」の意味を予...
  4. G20開幕 肺炎議題に 世界経済リスク、...

ニュース一覧

The Werner syndrome protein: linking the replication checkpoint response to genome stability.

著者 Pichierri P , Ammazzalorso F , Bignami M , Franchitto A
Aging (Albany NY).2011 Mar ; 3(3):311-8.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Genome stability group, Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy. pietro.pichierri@iss.it

スターを付ける スターを付ける     (286view , 0users)

Full Text Sources

Medical

Miscellaneous

The Werner syndrome protein (WRN) is a member of the human RecQ family DNA helicases implicated in the maintenance of genome stability. Loss of WRN gives rise to the Werner syndrome, a genetic disease characterised by premature aging and cancer predisposition. WRN plays a crucial role in the response to replication stress and significantly contributes to the recovery of stalled replication forks, although how this function is regulated is not fully appreciated. There is a growing body of evidence that WRN accomplishes its task in close connection with the replication checkpoint. In eukaryotic cells, the replication checkpoint response, which involves both the ATR and ATM kinase activities, is deputed to the maintenance of fork integrity and re-establishment of fork progression. Our recent findings indicate that ATR and ATM modulate WRN function at defined steps of the response to replication fork arrest. This review focuses on the novel evidence of a functional relationship between WRN and the replication checkpoint and how this cross-talk might contribute to prevent genome instability, a common feature of senescent and cancer cells.
PMID: 21389352 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード