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Determination and correlation of the reversed-phase thin-layer chromatographic parameter (Rm) of a series of 3-(4-substituted-1-piperazinyl)-1-substituted-1-phenyl propanol derivatives with their LD50 values.

著者 Patience O
Boll Chim Farm.2004 Jul-Aug ; 143(6):253-60.
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Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka - Nigeria.

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The experimental Rm values of four series of 3-(4-substituted-1- piperazinyl)-1-substituted-1-phenyl propanol derivatives, previously prepared for quantitative structure-activity relationship studies, were determined using reversed-phased thin-layer chromatography. The Rm values were determined for various concentrations of acetone in water (50, 60, 70, 80 and 90%), and the obtained correlation lines of Rm against proportion of acetone were extrapolated to 100% water The extrapolated Rm values of two of the four series of the 3-(4-benzyl-1-piperazinyl)-1-phenyl propanol derivatives were correlated with LD50 values obtained from 24-hour acute toxicity studies in albino mice. The extrapolated Rm values correlated parabolically with the LD50s.
PMID: 15881804 [PubMed - indexed for MEDLINE]
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