絞り込み

17443

広告

核燃料再処理工場 今月中にも正式合格の見通し 原子力規制委 (NHK)

青森県にある再処理工場の本格操業の前提となる審査の正式合格を判断する時期について原子力規制委員会の更田豊志委員長は、15日の記者会見で「作業は順調に進んでいる。...

  1. 芥川賞に高山羽根子さんと遠野遥さん 直木...
  2. [企業] Medicago社の植物から作...
  3. 指原莉乃さん 出身の大分県などに義援金2...
  4. 芥川賞に高山羽根子さん「首里の馬」と遠野...

ニュース一覧

Risperidone and clozapine in the treatment of drug-resistant schizophrenia and neuroleptic-induced supersensitivity psychosis.

著者 Chouinard G , Vainer JL , Bélanger MC , Turnier L , Beaudry P , Roy JY , Miller R この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Psychiatric Research Centre, Louis-H. Lafontaine Hospital, University of Montreal, Canada.

スターを付ける スターを付ける     (11view , 0users)

Medical

Miscellaneous

1. Supersensitivity psychosis (SSP) has emerged as a potential side effect of long-term neuroleptic therapy similar to tardive dyskinesia (TD). 2. Six schizophrenic patients with SSP, considered to be drug-resistant, were treated with risperidone, while another 5 were treated with clozapine. 3. The 6 risperidone-treated patients (all women) were rated on the Clinical Global Impression Improvement Scale as at least very much improved. Among the 5 clozapine-treated patients, all 4 men were found to have a marked response to clozapine, while the female patient was judged to be minimally improved. 4. It is hypothesized that not only TD but also SSP arise from destruction of cholinergic interneurons in the striatum as a consequence of prolonged neuroleptic administration. Thus, the drug-induced parkinsonism, which was proposed as mediating the antipsychotic effect of dopamine D2 blocking drugs, depends on the integrity of these cholinergic neurons. If these neurons are destroyed, drugs such as haloperidol lose their therapeutic effect. 5. In contrast, atypical neuroleptics like clozapine and risperidone reduce dopamine release in the striatum independently of prior production of extrapyramidal symptoms and, in this way, may be effective in psychotic illnesses unresponsive to classical anti-D2 neuroleptics. 6. In the present sample of patients, it is worth noting that schizophrenic men were good responders to clozapine. In comparison, risperidone was found to be efficacious in schizophrenic women.
PMID: 7531355 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード