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NCBP3/SNHG6 inhibits GBX2 transcription in a histone modification manner to facilitate the malignant biological behavior of glioma cells.

著者 Li X , Zhang F , Ma J , Ruan X , Liu X , Zheng J , Liu Y , Cao S , Shen S , Shao L , Cai H , Li Z , Xue Y
RNA Biol.2020 Jul 03 ; ():.
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RNA-binding proteins (RBPs) are significantly dysregulated in glioma. In this study, we demonstrated the upregulation of Nuclear cap binding subunit 3 (NCBP3) in glioma tissues and cells. Further, knockdown of NCBP3 inhibited the malignant progression of glioma. NCBP3 directly bound to small nucleolar RNA host gene 6 (SNHG6) and stabilized SNHG6 expression. In contrast, the gastrulation brain homeobox 2 (GBX2) transcription factor was downregulated in glioma tissues and cells. SNHG6 inhibited GBX2 transcription by mediating the H3K27me3 modification induced by polycomb repressive complex 2 (PRC2). Moreover, GBX2 decreased the promoter activities and downregulated the expression of the flotillin protein family 1 (FLOT1) oncogene. In conclusion, NCBP3/SNHG6 inhibits GBX2 transcription in a PRC2-dependent manner to facilitate the malignant progression of gliomas.
PMID: 32618493 [PubMed - as supplied by publisher]
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