絞り込み

16762

広告

Total Synthesis of (-)-Gardmultimine A.

著者 Chen P , Yang H , Zhang H , Chen W , Zhang Z , Zhang J , Li H , Wang X , Xie X , She X
Org Lett.2020 Feb 25 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (1view , 0users)

Full Text Sources

The first total synthesis of oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from d-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, and (3) an Au(I)-catalyzed transannular Conia-ene-type cyclization to establish the azabicyclo[2.2.2]octane skeleton and the exocyclic -alkene with exclusive stereoselectivity.
PMID: 32096647 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード