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Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity.

著者 Zhan Y , Kong I , Chopin M , Macri C , Zhang JG , Xie J , Nutt SL , O'Keeffe M , Hawkins ED , Morand EF , Lew AM
Immunol Cell Biol.2020 Jan 09 ; ():.
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The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. In contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellular abnormality associated with each parent strain remains unresolved. Given that plasmacytoid dendritic cells (pDCs) are key to the pathogenesis of lupus, we investigated the properties of pDCs from NZB and NZW mice. We found that NZB mouse had higher numbers of pDCs; much of the increase being contributed by a more abundant CD8 pDC subset. This was associated with prolonged survival and stronger proliferation of CD4 T cells. In contrast, NZW pDCs had heightened capacity to produce IFN-α and IFN-λ, and promoted stronger B-cell proliferation upon CpG-stimulation. Thus, our data reveal the different functional and numerical characteristics of pDCs from NZW and NZB mouse.
PMID: 31916630 [PubMed - as supplied by publisher]
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