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A truncated form of a transcription factor Mamo activates in embryos.

著者 Nakamura S , Hira S , Fujiwara M , Miyagata N , Tsuji T , Kondo A , Kimura H , Shinozuka Y , Hayashi M , Kobayashi S , Mukai M
Commun Biol.2019 ; 2():422.
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Expression of the gene is associated with germline establishment. Therefore, identification of activator(s) should provide insights into germline development. However, the genes sufficient for activation remain unknown. Previously, we showed that the BTB/POZ-Zn-finger protein Mamo is necessary for expression in . Here, we show that the truncated Mamo lacking the BTB/POZ domain (MamoAF) is a potent activator. Overexpression of MamoAF was sufficient to induce expression in both primordial germ cells and brain. Indeed, Mamo mRNA encoding a truncated Mamo isoform, which is similar to MamoAF, was predominantly expressed in primordial germ cells. The results of our genetic and biochemical studies showed that MamoAF, together with CBP, epigenetically activates expression. Furthermore, MamoAF and the germline transcriptional activator OvoB exhibited synergy in activating transcription. We propose that a Mamo-mediated network of epigenetic and transcriptional regulators activates expression.
PMID: 31799425 [PubMed - in process]
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