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USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation.

著者 Ling S , Shan Q , Zhan Q , Ye Q , Liu P , Xu S , He X , Ma J , Xiang J , Jiang G , Wen X , Feng Z , Wu Y , Feng T , Xu L , Chen K , Zhang X , Wei R , Zhang C , Cen B , Xie H , Song P , Liu J , Zheng S , Xu X
Gut.2019 Nov 27 ; ():.
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We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), and the mechanism they promote the stemness of hepatocellular carcinoma (HCC) cells under hypoxic conditions.
PMID: 31776228 [PubMed - as supplied by publisher]
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