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Blockade of adrenergic β-receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo.

著者 Wu H , Song Y , Li J , Lei X , Zhang S , Gao Y , Cheng P , Liu B , Miao S , Bi L , Yang L , Pei G
Cell Prolif.2019 Nov 20 ; ():e12725.
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Activation of the sympathetic system and adrenergic β-receptors following traumatic bone defects negatively impairs bone regeneration. Whether preventing β-receptor activation could potentially improve bone defect repair is unknown. In this study, we investigated the effect of systematic administration and local delivery of propranolol through composite scaffolds on bone healing.
PMID: 31746058 [PubMed - as supplied by publisher]
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