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Combined transcriptomic and proteomic analyses of cerebral frontal lobe tissue indentified RNA metabolism dysregulation as one potential pathogenic mechanism in cerebral autosomal dominant.

著者 Ritz MF , Jenoe P , Bonati L , Engelter S , Lyrer P , Peters N
Curr Neurovasc Res.2019 Oct 23 ; ():.
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Cerebral small vessel disease (SVD) is an important cause of stroke and vascular cognitive impairment (VCI), leading to subcortical ischemic vascular dementia. As a hereditary form of SVD with early onset, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents a pure form of SVD and may thus serve as a model disease for SVD. To date, underlying molecular mechanisms linking vascular pathology and subsequent neuronal damage in SVD are incompletely understood.
PMID: 31657685 [PubMed - as supplied by publisher]
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