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新型コロナ 寮の部員ら88人感染 松江の高校サッカー部 (毎日新聞)

松江市で新型コロナウイルスへの感染が明らかになった91人について、市と島根県は9日夜、88人が立正大淞南(しょうなん)高校(北村直樹校長、生徒数309人)のサッ...

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Chemical Composition and Biological Activities of Metabolites from the Marine Fungi sp. Isolated from Sediments of Co To Island, Vietnam.

著者 Le HMT , Do QT , Doan MHT , Vu QT , Nguyen MA , Vu THT , Nguyen HD , Duong NTT , Tran MH , Chau VM , Pham VC
Molecules.2019 Oct 24 ; 24(21):.
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Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (), 3-indolecarbaldehyde (), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (), 2-[(2-hydroxypropanoyl)amino]benzamide (), 4-hydroxybenzandehyde (), chrysogine (), 3-acetyl-4-hydroxycinnoline (), acid 1H-indole-3-acetic (), cyclo (Tyr-Trp) (), and 2',3'-dihydrosorbicillin (). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol () showed a strong inhibitory effect against with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2-hydroxypropanoyl)amino]benzamide () and 4-hydroxybenzandehyde () selectively inhibited with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2',3'-Dihydrosorbicillin () potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).
PMID: 31652901 [PubMed - in process]
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