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In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.

著者 Cuccarini V , Antelmi L , Pollo B , Paterra R , Calatozzolo C , Nigri A , DiMeco F , Eoli M , Finocchiaro G , Brenna G , Tramacere I , Bruzzone MG , Anghileri E
Neurol Sci.2019 Oct 24 ; ():.
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Isocitrate dehydrogenase 1/2 (IDH1/2) mutations are often detected in lower-grade gliomas (LGG) and result into 2-hydroxyglutarate (2HG) synthesis. Prior studies showed that 2HG can be detected in vivo using magnetic resonance spectroscopy (MRS), but its accuracy and translational impact are still under investigation.
PMID: 31650436 [PubMed - as supplied by publisher]
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