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Lipid Acyl Chain cis Double Bond Position Modulates Membrane Domain Registration/Anti-registration.

著者 Zhang S , Lin X
J Am Chem Soc.2019 Sep 18 ; ():.
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Inter-leaflet coupling is critical to control the dynamics of membrane domain registration/anti-registration, which is important in maintaining proper biological functions. Factors such as lipid acyl chain inter-digitation and membrane remodeling have been found to be able to regulate the inter-leaflet coupling. However, detailed molecular mechanisms that dominate the inter-leaflet coupling are still far from clear. Here, we revealed that lipid acyl chain cis double-bond position can regulate the inter-leaflet coupling according to our coarse-grained and all-atom molecular dynamics simulations. The farther the double bond is away from lipid tail terminal, the weaker inter-leaflet attractive interactions between unsaturated lipids. Therefore, the relative motions of membrane domains in two membrane leaflets become more obvious (membrane domain anti-registration). Generally, our simulations validated a direct indicator for the inter-leaflet coupling strength, which provides physical insights into molecular mechanisms of membrane domain registration/anti-registration.
PMID: 31532653 [PubMed - as supplied by publisher]
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