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Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach.

著者 Bockerstett KA , Lewis SA , Wolf KJ , Noto CN , Jackson NM , Ford EL , Ahn TH , DiPaolo RJ
Gut.2019 Sep 03 ; ():.
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Spasmolytic polypeptide-expressing metaplasia (SPEM) is a regenerative lesion in the gastric mucosa and is a potential precursor to intestinal metaplasia/gastric adenocarcinoma in a chronic inflammatory setting. The goal of these studies was to define the transcriptional changes associated with SPEM at the individual cell level in response to acute drug injury and chronic inflammatory damage in the gastric mucosa.
PMID: 31481545 [PubMed - as supplied by publisher]
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