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Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury.

著者 Liu JX , Yang C , Zhang WH , Su HY , Liu ZJ , Pan Q , Liu HF
Life Sci.2019 Aug 31 ; ():116828.
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The renal tubule cells require a large number of mitochondria to supply ATP due to their high-energy demand during reabsorption and secretion against chemical gradients and result in mitochondria susceptible to disorder and injury during stress conditions. Injured mitochondria are eventually degraded by mitophagy, and disturbances in mitophagy are associated with the pathogenesis of acute kidney injury (AKI) such as diabetic nephropathy and glomerulosclerosis. However, whether a disturbance in mitophagy has occurred and the role it plays in (SAKI) is still unclear. Therefore, the aim of this study was to investigate the key features of mitophagy and mitochondrial dynamics in sepsis-induced acute kidney injury (SAKI).
PMID: 31479679 [PubMed - as supplied by publisher]
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