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The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease.

著者 Pang SY , Ho PW , Liu HF , Leung CT , Li L , Chang EES , Ramsden DB , Ho SL
Transl Neurodegener.2019 ; 8():23.
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Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major constituent of LB, spreads to different regions of the brain in a prion-like fashion, giving rise to successive non-motor and motor symptoms. Etiology is likely multifactorial, and involves interplay among aging, genetic susceptibility and environmental factors.
PMID: 31428316 [PubMed]
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