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Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.

著者 Li S , Yao M , Niu C , Liu D , Tang Z , Gu C , Zhao H , Ke J , Wu S , Wang X , Wu F
Biochem Biophys Res Commun.2019 Jul 03 ; ():.
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Intracellular Ca signals play many important cellular functions such as migration, proliferation and differentiation. Store-operated Ca entry (SOCE) is a major route of Ca entry in nonexcitable cells. The activation of SOCE requires engagement between stromal interaction molecule 1 (STIM1) molecules on the endoplasmic reticulum and Ca release-activated Ca (CRAC) channel Orais (Orai1-3) on the plasma membrane. Accumulating evidence indicates that SOCE plays critical roles in cancer cell proliferation, invasion and metastasis. Here, we used the synthetic intracellular peptides derived from the C-termini of Orai channels to treat the breast cancer cells. We have found that Orai3-CT peptide exhibits stronger binding to STIM1 than Orai1-CT, and Orai3-CT peptide acts in a dominant negative fashion, blocking the STIM1-Orai1 interaction and reducing the Ca entry and proliferation of breast cancer cells.
PMID: 31279526 [PubMed - as supplied by publisher]
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