絞り込み

16645

広告

プラごみ解決探るDVD販売 (デイリースポーツ)

深刻化するプラスチックによる海洋汚染の現状や、焼却に頼る日本のリサイクル政策の問題点を指摘し、解決への道を探るビデオ「プラスチックごみ-日本のリサイクル幻想」を...

  1. [医学] ハンチンチンのリン酸化促進剤タ...
  2. 美容成分プロテオグリカン、脂質異常にも予...
  3. [医学] 臍帯の間質細胞と一緒に膵島細胞...
  4. [医学] 骨髄間質細胞のPKCβの阻害剤...

ニュース一覧

スターを付ける スターを付ける     (14view , 0users)

Full Text Sources

Miscellaneous

Other Literature Sources

Exhausted CD8 T cells (T) in chronic infections and cancer have limited effector function, high inhibitory receptor co-expression and extensive transcriptional changes compared to effector (T) or memory (T) CD8 T cells. T are important clinical targets of checkpoint blockade and other immunotherapies. Epigenetically, T are a distinct immune subset, with a unique chromatin landscape compared to T and T. However, the mechanisms governing the transcriptional and epigenetic development of T remain unknown. Here, we identify the HMG-box transcription factor TOX as a central regulator of T. TOX is largely dispensable for T and T formation, but is critical for exhaustion and without TOX T do not form. TOX is induced by calcineurin and NFAT2 and operates in a feed-forward loop to become calcineurin independent and sustained in T. Thus, robust TOX expression results in commitment to T by translating persistent stimulation into a distinct T transcriptional and epigenetic developmental program.
PMID: 31207603 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード