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TOX promotes the exhaustion of antitumor CD8 T cells by preventing PD1 degradation in hepatocellular carcinoma.

著者 Wang X , He Q , Shen H , Xia A , Tian W , Yu W , Sun B
J Hepatol.2019 Jun 04 ; ():.
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The thymocyte selection-associated high mobility group box protein (TOX) plays a vital role in T cell development and differentiation, however, its role in T cell exhaustion was unexplored. Here, we aim to investigate the role of TOX in regulating antitumor effect of CD8 T cells in hepatocellular carcinoma (HCC).
PMID: 31173813 [PubMed - as supplied by publisher]
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