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子どもを早産 親どうしがアプリを使い交流 悩みなど相談 (NHK)

早産などで産まれた赤ちゃんの親どうしが、自宅にいながら交流できる機会をつくろうと、当事者たちがスマートフォンなどのアプリを使った対面式の交流会に取り組んでいます...

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A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population.

著者 Zhu Y , Ke J , Gong Y , Yang Y , Peng X , Tian J , Zou D , Yang N , Wang X , Mei S , Rao M , Ying P , Deng Y , Wang H , Zhang H , Li B , Wan H , Li Y , Niu S , Cai Y , Zhang M , Lu Z , Zhong R , Miao X , Chang J
Cancer Med.2019 May 06 ; ():.
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Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K-AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathway. In order to investigate the associations between genetic variations in that pathway and pancreatic cancer prognosis, we conducted a two-stage survival analysis in a total of 547 Chinese pancreatic cancer patients. Consequently, a variant, rs13167294 A>C in PIK3R1, was significantly associated with poor survival in both stages and with hazard ratio being 1.32 (95% CI = 1.13-1.56, P = 0.0007) in the combined analysis. Function annotation and prediction suggested that genetic variants in this locus might affect overall survival of pancreatic cancer patients by regulating PIK3R1 expression.
PMID: 31059194 [PubMed - as supplied by publisher]
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