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Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease.

著者 La C , Linortner P , Bernstein JD , Ua Cruadhlaoich MAI , Fenesy M , Deutsch GK , Rutt BK , Tian L , Wagner AD , Zeineh M , Kerchner GA , Poston KL
Neuroimage Clin.2019 Apr 18 ; 23():101824.
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Parkinson's disease (PD) episodic memory impairments are common; however, it is not known whether these impairments are due to hippocampal pathology. Hippocampal Lewy-bodies emerge by Braak stage 4, but are not uniformly distributed. For instance, hippocampal CA1 Lewy-body pathology has been specifically associated with pre-mortem episodic memory performance in demented patients. By contrast, the dentate gyrus (DG) is relatively free of Lewy-body pathology. In this study, we used ultra-high field 7-Tesla to measure hippocampal subfields in vivo and determine if these measures predict episodic memory impairment in PD during life.
PMID: 31054380 [PubMed - as supplied by publisher]
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